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Multi-Peptide Adsorption on Uncharged Solid Surfaces: A Coarse-Grained Simulation Study Research

Ruosang Qiu, Jie Xiao, Xiao Dong Chen

Engineering 2020, Volume 6, Issue 2,   Pages 185-194 doi: 10.1016/j.eng.2018.12.012

Abstract: It was observed that around half (46.6%) of the 12-Ala peptide chains could form aggregates. 30.0% ofThe change in the solid-liquid interface due to peptide deposition has a potential influence on the furtheradsorption of single peptide chains and aggregates in the bulk water.Overall, the findings from this work help to reveal the mechanism of multi-peptide adsorption, and consequentially

Keywords： Peptide chains     Aggregates     Adsorption     Coarse-grained simulation    

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Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Frontiers of Chemical Science and Engineering 2014, Volume 8, Issue 4,   Pages 433-444 doi: 10.1007/s11705-014-1454-6

Abstract: Previous studies have found that three peptide inhibitors (i.e., KLVFF, VVIA, and LPFFD) can inhibitHowever, atomic details of binding modes and binding affinities between these peptide inhibitors andmolecular mechanics Poisson Boltzmann surface area (MM/PBSA) analysis, we examined the effect of three peptideMM/PBSA analysis further revealed that different peptide inhibitors have different modes of interactionprovides structure-based binding information for further modification and optimization of these three peptide

Keywords： Alzheimer’s disease     amyloid β-protein     peptide inhibitors     protein-protein interaction     molecular    

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Balancing resilience and efficiency in supply chains: Roles of disruptive technologies under Industry

Frontiers of Engineering Management   Pages 171-176 doi: 10.1007/s42524-022-0247-8

Abstract: In the Industry 4.0 era, disruptive technologies such as big data analytics, blockchain, Internet-of-Things, and additive manufacturing have become major forces driving supply chain transformation. Under such circumstances, particular attention should be attached to balancing resilience and efficiency of the supply chain, especially in the presence of more turbulence. In this study, we first summarize the conflicts between supply chain efficiency and supply chain resilience regarding practices and objectives. Then, we discuss the positive effects of disruptive technologies in improving resilience and efficiency. Afterwards, we propose a research agenda that covers both the influence mechanism and trade-off mechanism of these technologies in terms of resilience and efficiency.

Keywords： disruptive technologies     supply chain     resilience     efficiency     paradox     balance    

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Levelized costs of the energy chains of new energy vehicles targeted at carbon neutrality in China

Frontiers of Engineering Management   Pages 392-408 doi: 10.1007/s42524-022-0212-6

Abstract: The cost of energy chains is an important factor in the diffusion of NEVs.This study proposes a systematic framework that includes various (competing or coordinated) energy chainsThe levelized costs of three typical carbon-neutral energy chains are investigated using the life cycleResults show that the current well-to-pump levelized costs of the energy chains in China for BEVs, FCVsThis work also summarizes policy recommendations on developing energy chains to promote the diffusion

Keywords： energy chain     new energy vehicle     internal combustion engine vehicle     life cycle cost     technological learning    

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Cystine oligomers successfully attached to peptide cysteine-rich fibrils

Christian Bortolini,Mingdong Dong

Frontiers of Chemical Science and Engineering 2016, Volume 10, Issue 1,   Pages 99-102 doi: 10.1007/s11705-016-1554-6

Abstract: Amyloid peptides are renowned to be related to neurodegenerative diseases, however, a fruitful avenue is to employ them as high-performance nanomaterials. These materials benefit from the intrinsic outstanding mechanical robustness of the amyloid backbone made of -strands. In this work, we exploited amyloid-like fibrils as functional material to attach pristine L-cysteine aggregates (cystine oligomers) and gold nanoparticles, without the need of templating compounds. This work will open new avenues on functional materials design and their realisation.

Keywords： cysteine     peptide fibrils     gold nanoparticles     amyloids     oligomers     nanomaterials    

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Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Naci Topaloğlu,Adem Küçük,Şule Yıldırım,Mustafa Tekin,Havva Erdem,Mustafa Deniz

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 368-373 doi: 10.1007/s11684-015-0403-1

Abstract:

Glucagon-like peptide-2 (GLP-2) has potent anti-inflammatory effects and protects against experimental

Keywords： ischemia/reperfusion     liver     glucagon-like peptide-2     alanine aminotransferase    

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The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease

Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 437-442 doi: 10.1007/s11684-009-0074-x

Abstract: Natriuretic peptide precursor A (NPPA) is synthesized, stored, and released by atrial myocytes.

Keywords： natriuretic peptide precursor A     coronary heart disease     gene polymorphism     allelic discrimination     polymorphism    

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Improving the resilience of maritime supply chains: The integration of ports and inland transporters

Frontiers of Engineering Management   Pages 51-66 doi: 10.1007/s42524-022-0231-3

Abstract: integrate with inland logistics providers to improve the efficiency and resilience of maritime supply chainsThis study examines the strategic options of two competing maritime supply chains consisting of ports

Keywords： resilience     Hotelling model     social welfare     maritime supply chain     game theory    

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Resilience strategies for sustainable supply chains under budget constraints in the post COVID-19 era

Frontiers of Engineering Management   Pages 143-157 doi: 10.1007/s42524-022-0236-y

Abstract: The COVID-19 outbreak has caused uncertainty risk surges, increased sustainable supply chain vulnerabilities, and challenges to sustainable supply chain resilience (SSCR) management. Therefore, improving SSCR is necessary to alleviate vulnerabilities, and SSCR management must generate large capital investments. However, the economic downturn brought about by the COVID-19 epidemic has made some companies have limited budgets that can be used to improve SSCR. Therefore, the design of resilience solutions needs to fully consider the constraints of budgetary costs. Most of the existing related literature only discusses optimal resilience solutions under certain cost constraints, so such resilience solutions cannot be applied to most enterprises. In this study, we set the cost constraint as a variable quantity, using resilience efficiency and customer satisfaction as indicators, to determine the changing laws of optimal resilience strategies when cost constraints change. These rules can be applied to enterprises with different budgeted costs. Our findings suggest that companies should prioritize sacrificing resilience measures (RMs) related to adaptive capacity when budget costs gradually decline, and RMs related to absorptive capacity are indispensable at all budget levels. Furthermore, the pursuit of environmental and social sustainability cannot be abandoned, no matter how limited the flexible budget may be.

Keywords： sustainable supply chain     customer requirement     resilience efficiency     customer satisfaction     budget constraint    

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Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 9-19 doi: 10.1007/s11705-013-1306-9

Abstract: innovative silica-based, mucoadhesive oral insulin formulation with encapsulated-insulin/cell penetrating peptideIt was also confirmed that low molecular weight protamine (LMWP) behaves like a CPP peptide, with a celldevelopment of a generic platform for oral delivery of many other bioactive compounds, especially for peptide

Keywords： insulin     cell penetrating peptide     mucoadhesive composites     oral delivery    

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Preparing construction supply chains for blockchain technology: An investigation of its potential and

Algan TEZEL, Eleni PAPADONIKOLAKI, Ibrahim YITMEN, Per HILLETOFTH

Frontiers of Engineering Management 2020, Volume 7, Issue 4,   Pages 547-563 doi: 10.1007/s42524-020-0110-8

Abstract: being slow in embracing emerging technologies and not effectively diffusing them through its supply chainsindustries like finance and banking, this study investigates the preparation of construction supply chains

Keywords： blockchain     smart contract     supply chain management     project management     construction    

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Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation

Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,

Engineering doi: 10.1016/j.eng.2023.01.015

Abstract: In particular, a designed antifreeze peptide named AVD exhibits ideal ice recrystallization inhibitionanalysis and molecular dynamics (MD) simulations indicated that the Thr6 and Asn8 residues of the AVD peptideFurthermore, to demonstrate the cryoprotection potential of AVD, the peptide was successfully employedThis work opens up a new avenue for designing antifreeze materials and provides peptide-based functional

Keywords： Antifreeze peptides     Evolution analysis     Ice recrystallization inhibition     Molecular dynamics simulation     Cryopreservation     Synthetic biology    

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Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating

Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 5,   Pages 889-901 doi: 10.1007/s11705-020-1919-8

Abstract: Herein, the multitargeting REDV-G-TAT-G-NLS peptide was conjugated to amphiphilic cationic copolymerECs-targeting ability, cell-penetrating ability and nuclear targeting capacity of REDV-G-TAT-G-NLS peptide

Keywords： gene carriers     multitargeting function     ECs     transfection efficiency    

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Reducing environmental impacts through socioeconomic transitions: critical review and prospects

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 2, doi: 10.1007/s11783-023-1624-1

Abstract:

● Reducing environmental impacts through socioeconomic structural transitions.

Keywords： Environmental pressures     Environmental impacts     Nexus     Supply chains     Trade     Coupled systems    

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Erratum to: Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting

Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng

Frontiers of Chemical Science and Engineering 2021, Volume 15, Issue 1,   Pages 220-220 doi: 10.1007/s11705-020-1995-9

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Title Author Date Type Operation

Multi-Peptide Adsorption on Uncharged Solid Surfaces: A Coarse-Grained Simulation Study

Ruosang Qiu, Jie Xiao, Xiao Dong Chen

Journal Article

Atomistic characterization of binding modes and affinity of peptide inhibitors to amyloid-

Fufeng LIU,Wenjie DU,Yan SUN,Jie ZHENG,Xiaoyan DONG

Journal Article

Balancing resilience and efficiency in supply chains: Roles of disruptive technologies under Industry

Journal Article

Levelized costs of the energy chains of new energy vehicles targeted at carbon neutrality in China

Journal Article

Cystine oligomers successfully attached to peptide cysteine-rich fibrils

Christian Bortolini,Mingdong Dong

Journal Article

Glucagon-like peptide-2 exhibits protective effect on hepatic ischemia-reperfusion injury in rats

Naci Topaloğlu,Adem Küçük,Şule Yıldırım,Mustafa Tekin,Havva Erdem,Mustafa Deniz

Journal Article

The role of natriuretic peptide precursor A gene polymorphism in the development of coronary heart disease

Ripen NSENGA MD, Longxian CHENG PhD, Mei’an HE PhD, Tangchun WU PhD,

Journal Article

Improving the resilience of maritime supply chains: The integration of ports and inland transporters

Journal Article

Resilience strategies for sustainable supply chains under budget constraints in the post COVID-19 era

Journal Article

Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Journal Article

Preparing construction supply chains for blockchain technology: An investigation of its potential and

Algan TEZEL, Eleni PAPADONIKOLAKI, Ibrahim YITMEN, Per HILLETOFTH

Journal Article

Rational Design of and Mechanism Insight into an Efficient Antifreeze Peptide for Cryopreservation

Haishan Qi,Yihang Gao,Lin Zhang,Zhongxin Cui,Xiaojie Sui,Jianfan Ma,Jing Yang,Zhiquan Shu,Lei Zhang,

Journal Article

Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting, penetrating

Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng

Journal Article

Reducing environmental impacts through socioeconomic transitions: critical review and prospects

Journal Article

Erratum to: Multifunctional peptide conjugated amphiphilic cationic copolymer for enhancing ECs targeting

Xinghong Duo, Lingchuang Bai, Jun Wang, Jintang Guo, Xiangkui Ren, Shihai Xia, Wencheng Zhang, Abraham Domb, Yakai Feng

Journal Article